| Manuscript | Link |
| Weitere Publikationen nach Projektende sind auf der e:Med-Webseite zu finden. |
| 2023 |
| Pennitz P, Goekeri C, Trimpert J, Wyler E, Ebenig A, Weissfuss C, Mühlebach MD, Witzenrath M, Nouailles G. Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis. STAR Protoc. 2022 Dec 20;4(1):101957. |
https://pubmed.ncbi.nlm.nih.gov/36542521/ |
| 2022 |
| Felten M, Ferencik S, Teixeira Alves LG, Letsiou E, Lienau J, Müller-Redetzky HC, Langenhagen AK, Voß A, Dietert K, Kershaw O, Gruber AD, Michalick L, Kuebler WM, Ananthasubramaniam B, Maier B, Uhlenhaut H, Kramer A, Witzenrath M. Ventilator-induced Lung Injury Is Modulated by the Circadian Clock. Am J Respir Crit Care Med. 2022 Dec 8. |
https://pubmed.ncbi.nlm.nih.gov/36480958/ |
| Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F. Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study. Infection. 2022 Dec;50(6):1441-1452. |
https://pubmed.ncbi.nlm.nih.gov/35420370/ |
| Vlaar APJ, Witzenrath M, van Paassen P, Heunks LMA, Mourvillier B, de Bruin S, Lim EHT, Brouwer MC, Tuinman PR, Saraiva JFK, Marx G,
Lobo SM, Boldo R, Simon-Campos JA, Cornet AD, Grebenyuk A, Engelbrecht JM, Mukansi M, Jorens PG, Zerbib R, Rückinger S, Pilz K, Guo R,
van de Beek D, Riedemann NC; PANAMO study group. Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically
ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Respir
Med. 2022 Dec;10(12):1137-1146. |
https://pubmed.ncbi.nlm.nih.gov/36087611/ |
| Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC. Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus. Sci Rep. 2022 Nov 29;12(1):20608. |
https://pubmed.ncbi.nlm.nih.gov/36446841/ |
| Lingscheid T, Kinzig M, Krüger A, Müller N, Bölke G, Tober-Lau P, Münn F, Kriedemann H, Witzenrath M, Sander LE, Sörgel F, Kurth F. Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0122922. |
https://pubmed.ncbi.nlm.nih.gov/36286542/ |
| Ni B, Chen S, Ryan KA, Maitland ML, Farrar JS, Witzenrath M, Gubier B, Serdjebi C, Bertotti K, Wang R, Salloum FN, Marino L, Mitchell BD, Celi FS. Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome. Mol Metab. 2022 Nov;65:101588. |
https://pubmed.ncbi.nlm.nih.gov/36055577/ |
| Steinbeis F, Knape P, Mittermaier M, Helbig ET, Tober-Lau P, Thibeault C, Lippert LJ, Xiang W, Müller-Plathe M, Steinbrecher S, Meyer HJ, Ring RM, Ruwwe-Glösenkamp C, Alius F, Li Y, Müller-Redetzky H, Uhrig A, Lingscheid T, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Witzenrath M, Zoller T. Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents. Respir Med. 2022 Oct;202:106968. |
https://pubmed.ncbi.nlm.nih.gov/36081267/ |
| Lask A, Gutbier B, Kershaw O, Nouailles G, Gruber AD, Müller-Redetzky HC, Chackowicz S, Hamilton DA, Van Slyke P, Witzenrath M. Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice. Sci Rep. 2022 Sep 15;12(1):15531. |
https://pubmed.ncbi.nlm.nih.gov/36109537/ |
| Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M,
Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G. A pulmonologist's guide to
perform and analyse cross-species single lung cell transcriptomics. Eur Respir Rev. 2022 Jul 27;31(165):220056. |
https://pubmed.ncbi.nlm.nih.gov/35896273/ |
| Kheifetz Y, Kirsten H, Scholz M. On the Parametrization of Epidemiologic Models-Lessons from Modelling COVID-19 Epidemic. Viruses. 2022 Jul 2;14(7):1468. |
https://pubmed.ncbi.nlm.nih.gov/35891447/ |
| Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G. Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection. J Clin Invest. 2022 Jul 1;132(13):e150951. |
https://pubmed.ncbi.nlm.nih.gov/35503420/ |
| Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group; Rubelt F, Heidecker B. Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19. EClinicalMedicine. 2022 Jun;48:101438. |
https://pubmed.ncbi.nlm.nih.gov/35600330/ |
| Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J. Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics. Mol Ther. 2022 May 4;30(5):1952-1965. |
https://pubmed.ncbi.nlm.nih.gov/35339689/ |
| Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC,
Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group; Bertrams W,
Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS
severity. JCI Insight. 2022 Feb 8;7(3):e149870. |
https://pubmed.ncbi.nlm.nih.gov/35132956/ |
| Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group. A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany. Eur Respir J. 2022 Feb 3;59(2):2102432. |
https://pubmed.ncbi.nlm.nih.gov/34824055/ |
| Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M. Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia. Genes (Basel). 2022 Jan 6;13(1):111. |
https://pubmed.ncbi.nlm.nih.gov/35052452/ |
| 2021 |
| Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M. Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection. Viruses. 2021 Dec 24;14(1):33. |
https://pubmed.ncbi.nlm.nih.gov/35062236/ |
| Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI); Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell. 2021 Dec 22;184(26):6243-6261.e27. |
https://pubmed.ncbi.nlm.nih.gov/34914922/ |
| Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M. Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst. Sci Rep. 2021 May 5;11(1):9529. |
https://pubmed.ncbi.nlm.nih.gov/33953279/ |
| Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS. Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings. Eur J Heart Fail. 2021 Nov;23(11):1891-1902. |
https://pubmed.ncbi.nlm.nih.gov/33932255/ |
| Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine. 2021 Oct;40:101099. |
https://pubmed.ncbi.nlm.nih.gov/34490415/ |
| Jung AL, Schmeck B, Wiegand M, Bedenbender K, Benedikter BJ. The clinical role of host and bacterial-derived extracellular vesicles in pneumonia. Adv Drug Deliv Rev. 2021 Sep;176:113811. |
https://pubmed.ncbi.nlm.nih.gov/34022269/ |
| Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Ralser M, Kurth F. A time-resolved proteomic and prognostic map of COVID-19. Cell Syst.
2021 Aug 18;12(8):780-794.e7. |
https://pubmed.ncbi.nlm.nih.gov/34139154/ |
| Witzenrath M, Kuebler WM. The CypA-netics of Ventilator-induced Lung Injury. Am J Respir Crit Care Med. 2021 Aug 15;204(4):385-387. |
https://pubmed.ncbi.nlm.nih.gov/34033522/ |
| Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M. Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19. Nat Commun. 2021 Aug 11;12(1):4869. |
https://pubmed.ncbi.nlm.nih.gov/34381043/ |
| Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S,
Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C,
Suttorp N, Witzenrath M, Sander LE, Hübner RH. CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are
associated with disease severity. Infection. 2021 Aug;49(4):757-762. |
https://pubmed.ncbi.nlm.nih.gov/33825125/ |
| Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M. Ultra-fast proteomics with Scanning SWATH. Nat Biotechnol. 2021 Jul;39(7):846-854. |
https://pubmed.ncbi.nlm.nih.gov/33767396 |
| Jagdmann S, Berchtold D, Gutbier B, Witzenrath M, Meisel A, Meisel C, Dames C. Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections. J Neuroimmunol. 2021 Jun 15;355:577568. |
https://pubmed.ncbi.nlm.nih.gov/33862420/ |
| Roessler FK, Benedikter BJ, Schmeck B, Bar N. Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples. Sci Rep. 2021 May 13;11(1):10258. |
https://pubmed.ncbi.nlm.nih.gov/33986404/ |
| Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M. Neutrophil-Derived Extracellular
Vesicles Activate Platelets after Pneumolysin Exposure. Cells. 2021 Dec 18;10(12):3581. |
https://pubmed.ncbi.nlm.nih.gov/34944089/ |
| Ochs M, Timm S, Elezkurtaj S, Horst D, Meinhardt J, Heppner FL, Weber-Carstens S, Hocke AC, Witzenrath M. Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient. Eur Respir J. 2021 May 6;57(5):2004165. |
https://pubmed.ncbi.nlm.nih.gov/33446606 |
| Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN. Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes. RNA Biol. 2021 May;18(5):604-618. |
https://pubmed.ncbi.nlm.nih.gov/33622174 |
| Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M. Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L916-L925. |
https://pubmed.ncbi.nlm.nih.gov/33655757 |
| Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B. Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection. Life Sci. 2021 Apr 1;270:119158. |
https://pubmed.ncbi.nlm.nih.gov/33545200 |
| Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM. Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure. Eur Respir J. 2021 Mar 11;57(3):2002384. |
https://pubmed.ncbi.nlm.nih.gov/33154030/ |
| Vera J, Lischer C, Nenov M, Nikolov S, Lai X, Eberhardt M. Mathematical Modelling in Biomedicine: A Primer for the Curious and the Skeptic. Int J Mol Sci. 2021 Jan 7;22(2):547. |
https://pubmed.ncbi.nlm.nih.gov/33430432 |
| Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A. Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells. J Cyst Fibros. 2021 Jan;20(1):140-148. (juni 2020 epub) |
https://pubmed.ncbi.nlm.nih.gov/32534959 |
| 2020 |
| Karwelat D, Schmeck B, Ringel M, Benedikter BJ, Hübner K, Beinborn I, Maisner A, Schulte LN, Vollmeister E. Influenza virus-mediated suppression of bronchial Chitinase-3-like 1 secretion promotes secondary pneumococcal infection. FASEB J. 2020 Dec;34(12):16432-16448. |
https://pubmed.ncbi.nlm.nih.gov/33095949 |
| Ahnert P, Scholz M. modellierung von infektionserkrankungen der atemwege. Systemmedizinische Modellierung von Therapieoptionen bei ambulant erworbener Pneumonie und COVID-19. In Systembiologie.de. Ausgabe 13 Dezember 2020. |
https://www.systembiologie.de/lw_resource/datapool/systemfiles/elements/files/B6AA5AC509E249CBE0537E695E866DB2/live/document/PTJ-007_gesundhyte_13_2020_201217_WEB_300dpi_klein.pdf |
| Schirm S, Ahnert P, Berger S, Nouailles G, Wienhold SM, Müller-Redetzky H, Suttorp N, Loeffler M, Witzenrath M, Scholz M. A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection. PLoS One. 2020 Dec 3;15(12):e0243147. |
https://pubmed.ncbi.nlm.nih.gov/33270742 |
| Mittermaier M, Pickerodt P, Kurth F, de Jarcy LB, Uhrig A, Garcia C, Machleidt F, Pergantis P, Weber S, Li Y, Breitbart A, Bremer F, Knape P, Dewey M, Doellinger F, Weber-Carstens S, Slutsky AS, Kuebler WM, Suttorp N, Müller-Redetzky H. Evaluation of PEEP and prone positioning in early COVID-19 ARDS. EClinicalMedicine. 2020 Nov;28:100579. |
https://pubmed.ncbi.nlm.nih.gov/33073217 |
| Santos G, Vera J. The Role of Age, Neutrophil Infiltration and Antibiotics Timing in the Severity of Streptococcus pneumoniae Pneumonia. Insights from a Multi-Level Mathematical
Model Approach. Int J Mol Sci. 2020 Nov 10;21(22):8428. doi: 10.3390/ijms21228428. |
https://pubmed.ncbi.nlm.nih.gov/33182614/ |
| Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A. SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature. 2020 Nov;587(7833):270-274. |
https://pubmed.ncbi.nlm.nih.gov/32726801 |
| Schmidt M, Hopp L, Arakelyan A, Kirsten H, Engel C, Wirkner K, Krohn K, Burkhardt R, Thiery J, Loeffler M, Loeffler-Wirth H, Binder H. The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health. Front Big Data. 2020 Oct 30;3:548873. |
https://pubmed.ncbi.nlm.nih.gov/33693414 |
| Korfhage N, Mühling M, Ringshandl S, Becker A, Schmeck B, Freisleben B. Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion. PLoS Comput Biol. 2020 Sep 8;16(9):e1008179. |
https://pubmed.ncbi.nlm.nih.gov/32898132 |
| Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat Biotechnol. 2020 Aug;38(8):970-979. |
https://pubmed.ncbi.nlm.nih.gov/32591762 |
| Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M. Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection. Cell Syst. 2020 Jul 22;11(1):11-24.e4. |
https://pubmed.ncbi.nlm.nih.gov/32619549 |
| Nikoghosyan M, Schmidt M, Margaryan K, Loeffler-Wirth H, Arakelyan A, Binder H. SOMmelier-Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. Genes (Basel). 2020 Jul 17;11(7):817. |
https://pubmed.ncbi.nlm.nih.gov/32709105 |
| Mikolajewska, A., and M. Witzenrath (2020). „Ambulant erworbene Pneumonie bei Erwachsenen.“ Dtsch med Wochenschr 145(06): 359–370. |
http://doi.org/10.1055/a-0993-0874 |
| Sanapala SR, Seco BMS, Baek JY, Awan SI, Pereira CL, Seeberger PH. Chimeric oligosaccharide conjugate induces opsonic antibodies against Streptococcus pneumoniae serotypes 19A and 19F. Chem Sci. 2020 Jun 26;11(28):7401-7407. |
https://pubmed.ncbi.nlm.nih.gov/34123020 |
| Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE,
Schmeck B, Schulte LN. Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):9042-9053. doi:
10.1073/pnas.1920393117. Epub 2020 Apr 2. |
https://www.ncbi.nlm.nih.gov/pubmed/32209695 |
| Ochs M, Hegermann J, Lopez-Rodriguez E, Timm S, Nouailles G, Matuszak J, Simmons S, Witzenrath M, Kuebler WM. On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx. Int J Mol Sci. 2020 Apr 27;21(9):3075. |
https://pubmed.ncbi.nlm.nih.gov/32349261 |
| Müller-Redetzky H, Kellermann U, Wienhold SM, Gutbier B, Lienau J, Hellwig K, Reppe K, Letsiou E, Tschernig T, Scholz M, Ahnert P,
Maasch C, Hoehlig K, Klussmann S, Vater A, Firsching TC, Hoppe J, Suttorp N, Witzenrath M. Neutralizing Complement C5a Protects
Mice with Pneumococcal Pulmonary Sepsis.
Anesthesiology. 2020 Feb 20. doi: 10.1097/ALN.0000000000003149. |
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| Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M,
Marsico A, Bertrams W, Schmeck B. A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
mBio. 2020 Mar 24;11(2). pii: e03155-19. doi: 10.1128/mBio.03155-19. |
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| Thalheim T, Hopp L, Herberg M, Siebert S, Kerner C, Quaas M, Schweiger MR, Aust G, Galle J. Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells. Int J Mol Sci. 2020 Mar 12;21(6):1941. |
https://pubmed.ncbi.nlm.nih.gov/32178409 |
| Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E.
NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells. Cell Signal.
2020 Mar;67:109498. doi:10.1016/j.cellsig.2019.109498. Epub 2019 Dec 16. |
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| Przybilla J, Ahnert P, Bogatsch H, Bloos F, Brunkhorst FM, SepNet Critical Care Trials Group, Progress Study Group, Bauer M, Loeffler M, Witzenrath M, Suttorp N, Scholz M.
Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia. J Clin Med. 2020 Feb 5;9(2). pii: E393. doi: 10.3390/jcm9020393. |
https://www.ncbi.nlm.nih.gov/pubmed/32121038 |
| Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier CF, Vera J, Schmeck B.
Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation.
Sci Rep. 2020 Jan 14;10(1):241. doi: 10.1038/s41598-019-57108-0. |
https://www.ncbi.nlm.nih.gov/pubmed/31937830 |
| Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, Auf Dem Brinke K,
Timmesfeld N, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Suttorp N,
Schmeck B. Surface Proteome of Plasma Extracellular Vesicles as Biomarkers
for
Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease. J
Infect Dis. 2020 Jan 2;221(2):325-335. doi: 10.1093/infdis/jiz460. |
https://www.ncbi.nlm.nih.gov/pubmed/31617573 |
| 2019 |
| Jensen AV, Baunbæk Egelund G, Bang Andersen S, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P, Faurholt-Jepsen D; Members of the CAPNETZ study group except the authors:. The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study. Ann Am Thorac Soc. 2019 Dec;16(12):1518-1526. |
https://pubmed.ncbi.nlm.nih.gov/31437014 |
| Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY,
Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M.
IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun. 2019 Dec 16;10(1):5722. doi:
10.1038/s41467-019-13731-z. |
https://www.ncbi.nlm.nih.gov/pubmed/31844089 |
| Lindhauer NS, Bertrams W, Pöppel A, Herkt CE, Wesener A, Hoffmann K, Greene
B,Van Der Linden M, Vilcinskas A, Seidel K, Schmeck B. Antibacterial activity
of a Tribolium castaneum defensin in an in vitro infection model of
Streptococcuspneumoniae. Virulence. 2019 Dec;10(1):902-909. | https://www.ncbi.nlm.nih.gov/pubmed/31657264 |
| Meyer TC, Schmidt F, Steinke J, Bröker BM, Völker U, Michalik S. Technical
report: xMAPr - High-dynamic-range (HDR) quantification of antigen-specific
antibody binding. J Proteomics. 2019 Nov 1:103577. doi:
10.1016/j. | https://www.ncbi.nlm.nih.gov/pubmed/31683064 |
| Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber
AD,Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N,
HainT, Zahlten J. Peptidoglycan Recognition Protein 4 Limits Bacterial
Clearance and Inflammation in Lungs by Control of the Gut Microbiota. Front
Immunol. 2019 Sep20;10:2106. doi: 10.3389/fimmu.2019.02106. eCollection
2019. | https://www.ncbi.nlm.nih.gov/pubmed/31616404 |
| Blankenburg S, Hentschker C, Nagel A, Hildebrandt P, Michalik S, Dittmar D,
Surmann K, Völker U. Improving Proteome Coverage for Small Sample Amounts: An
Advanced Method for Proteomics Approaches with Low Bacterial Cell Numbers.
Proteomics. 2019 Sep 18:e1900192. doi: 10.1002/pmic.201900192. | https://www.ncbi.nlm.nih.gov/pubmed/31532911 |
| Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019 Aug 7. pii: JVI.00649-19. doi: 10.1128/JVI.00649-19. | https://www.ncbi.nlm.nih.gov/pubmed/31391268 |
| Franssen FM, Alter P, Bar N, Benedikter BJ, Iurato S, Maier D, Maxheim M, Roessler FK, Spruit MA, Vogelmeier CF, Wouters EF, Schmeck B. Personalized medicine for patients with COPD: where are we? Int J Chron Obstruct Pulmon Dis. 2019 Jul 9;14:1465-1484. |
https://pubmed.ncbi.nlm.nih.gov/31371934 |
| Brack MC, Lienau J, Kuebler WM, Witzenrath M. Cardiovascular sequelae of pneumonia. Curr Opin Pulm Med. 2019 May;25(3):257-262. doi: 10.1097/MCP.0000000000000584. | https://www.ncbi.nlm.nih.gov/pubmed/30893107 |
| Nikoghosyan M, Hakobyan S, Hovhannisyan A, Loeffler-Wirth H, Binder H, Arakelyan A. Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians - A Machine Learning Approach. Front Genet. 2019 Apr 26;10:394. |
https://pubmed.ncbi.nlm.nih.gov/31105750 |
| Loeffler-Wirth H, Kreuz M, Hopp L, Arakelyan A, Haake A, Cogliatti SB, Feller AC, Hansmann ML, Lenze D, Möller P, Müller-Hermelink HK, Fortenbacher E, Willscher E, Ott G, Rosenwald A, Pott C, Schwaenen C, Trautmann H, Wessendorf S, Stein H, Szczepanowski M, Trümper L, Hummel M, Klapper W, Siebert R, Loeffler M, Binder H; German Cancer Aid consortium Molecular Mechanisms for Malignant Lymphoma. A modular transcriptome map of mature B cell lymphomas. Genome Med. 2019 Apr 30;11(1):27. |
https://pubmed.ncbi.nlm.nih.gov/31039827 |
| Wienhold SM, Lienau J, Witzenrath M. Towards Inhaled Phage Therapy in Western Europe. Viruses. 2019 Mar 23;11(3). pii: E295. doi: 10.3390/v11030295. | https://www.ncbi.nlm.nih.gov/pubmed/30909579 |
| Regier Y, Komma K, Weigel M, Kraiczy P, Laisi A, Pulliainen AT, Hain T, Kempf VAJ. Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany. Parasit Vectors. 2019 Jan 7;12(1):11. |
https://pubmed.ncbi.nlm.nih.gov/30616666 |
| Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B. Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. J Infect Dis. 2019 Jan 29;219(4):540-543. |
https://pubmed.ncbi.nlm.nih.gov/30239899 |
| Schulte LN, Bertrams W, Stielow C, Schmeck B. ncRNAs in Inflammatory and Infectious Diseases. Methods Mol Biol. 2019;1912:3-32. |
https://pubmed.ncbi.nlm.nih.gov/30635888 |
| 2018 |
| Regier Y, Komma K, Weigel M, Pulliainen AT, Göttig S, Hain T, Kempf VAJ. Microbiome Analysis Reveals the Presence of Bartonella spp. and Acinetobacter spp. in Deer Keds (Lipoptena cervi). Front Microbiol. 2018 Dec 20;9:3100. |
https://pubmed.ncbi.nlm.nih.gov/30619179 |
| Kaplonek P, Khan N, Reppe K, Schumann B, Emmadi M, Lisboa MP, Xu FF, Calow ADJ, Parameswarappa SG, Witzenrath M, Pereira CL, Seeberger PH. Improving vaccines against Streptococcus pneumoniae using synthetic glycans. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13353-13358. doi: 10.1073/pnas.1811862115. | https://www.ncbi.nlm.nih.gov/pubmed/30530654 |
| Berger S, Goekeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M, Nouailles G. Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia. Crit Care. 2018 Nov 1;22(1):287. doi: 10.1186/s13054-018-2224-5. | https://www.ncbi.nlm.nih.gov/pubmed/?term=30382866 |
| Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky H. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice. Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8. | https://www.ncbi.nlm.nih.gov/pubmed/?term=30373626 |
| Marin-Sanguino A, Vera J, Alves R. Editorial: Foundations of Theoretical Approaches in Systems Biology. Front Genet. 2018 Aug 15;9:290. doi: 10.3389/fgene.2018.00290. | https://www.ncbi.nlm.nih.gov/pubmed/30158950 |
| Vera J, Santos G. Can Gamification Contribute to Computer Modeling-Driven Biomedical Research? Front Physiol. 2018 Jul 19;9:908. doi: 10.3389/fphys.2018.00908. eCollection 2018. | https://www.ncbi.nlm.nih.gov/pubmed/?term=30072911 |
| Hopp L, Loeffler-Wirth H, Nersisyan L, Arakelyan A, Binder H. Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. Front Immunol. 2018 Jul 17;9:1620. doi: 10.3389/fimmu.2018.01620 | https://www.ncbi.nlm.nih.gov/pubmed/30065722 |
| Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡. Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC. | https://www.ncbi.nlm.nih.gov/pubmed/29447449 |
| Santos G, Lai X, Eberhardt M, Vera J. Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling. Front Cell Infect Microbiol. 2018 May 15;8:159. doi: 10.3389/fcimb.2018.00159. eCollection 2018. | https://www.ncbi.nlm.nih.gov/pubmed/29868515 |
| Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD. Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia. Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA. | https://www.ncbi.nlm.nih.gov/pubmed/29361238 |
| Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH. Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1. ACS Cent Sci. 2018 Mar 28;4(3):357-361. doi: 10.1021/acscentsci.7b00504. | https://www.ncbi.nlm.nih.gov/pubmed/29632881 |
| Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916. | https://www.ncbi.nlm.nih.gov/pubmed/29298188 |
| Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznicka M, Cambier J, Witzenrath M, Schumann RR, Suttorp N, Opitz B. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infect Immun. 2018 Feb 20;86(3). pii: e00849-17. doi: 10.1128/IAI.00849-17. | https://www.ncbi.nlm.nih.gov/pubmed/29263110 |
| Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group. The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. PLoS Pathog. 2018 Jan 3;14(1):e1006829. doi: 10.1371/journal.ppat.1006829. | https://www.ncbi.nlm.nih.gov/pubmed/29298342 |
| 2017 |
| Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ); German Community-Acquired Pneumonia Competence Network (CAPNETZ). Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study. Clin Infect Dis. 2017 Nov 29;65(12):2091-2098. doi: 10.1093/cid/cix703. | https://www.ncbi.nlm.nih.gov/pubmed/29095981 |
| Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M. Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia. Crit Care. 2017 Nov 13;21(1):274. doi: 10.1186/s13054-017-1851-6. | https://www.ncbi.nlm.nih.gov/pubmed/29132435 |
| Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M. A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae. Angew Chem Int Ed Engl. 2017 Nov 6;56(45):13973-13978. doi: 10.1002/anie.201700964. | https://www.ncbi.nlm.nih.gov/pubmed/28815890 |
| Arakelyan A, Nersisyan L, Poghosyan D, Khondkaryan L, Hakobyan A, Löffler-Wirth H, Melanitou E, Binder H. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS One. 2017 Nov 3;12(11):e0187572. doi: 10.1371/journal.pone.0187572. | https://www.ncbi.nlm.nih.gov/pubmed/?term=29099860 |
| Emmadi M, Khan N, Lykke L, Reppe K, G Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH. A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease. J Am Chem Soc. 2017 Oct 18;139(41):14783-14791. doi: 10.1021/jacs.7b07836. | https://www.ncbi.nlm.nih.gov/pubmed/28945368 |
| Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH. Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11063-11068. doi: 10.1073/pnas.1706875114. | https://www.ncbi.nlm.nih.gov/pubmed/28973947 |
| Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep. 2017 Sep 20;7(1):11988. doi: 10.1038/s41598-017-12154-4. | https://www.ncbi.nlm.nih.gov/pubmed/?term=28931863 |
| Cantone M, Santos G, Wentker P, Lai X, Vera J. Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection. Front Physiol. 2017 Aug 30;8:645. doi: 10.3389/fphys.2017.00645 | https://www.ncbi.nlm.nih.gov/pubmed/?term=28912729 |
| Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep. 2017 Jul 24;7(1):6301. doi: 10.1038/s41598-017-06443-1. | https://www.ncbi.nlm.nih.gov/pubmed/28740179 |
| Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection andtargets NTAN1. PLoS One. 2017 Apr 26;12(4):e0176204. doi:10.1371/journal.pone.0176204 | https://www.ncbi.nlm.nih.gov/pubmed/28445535 |
| Schumann, B., Hahm, H.S., Parameswarappa, S.G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C.L., Seeberger, P.H., 2017. A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Sci Transl Med. 2017 Mar 8;9(380). pii: eaaf5347. doi: 10.1126/scitranslmed.aaf5347. | https://www.ncbi.nlm.nih.gov/pubmed/28275152 |
| Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017 Mar 1;198(5):2191-2201. doi: 10.4049/jimmunol.1502513. | https://www.ncbi.nlm.nih.gov/pubmed/?term=28137890 |
| Jung, A.L., Hoffmann, K., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2017. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp. 2017 Feb 22;(120). doi: 10.3791/55146. | https://www.ncbi.nlm.nih.gov/pubmed/28287548 |
| 2016 |
| Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2016. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie 70, 372-378. | http://doi.org/10.1055/s-0035-1563788 |
| Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47-56. | http://doi.org/10.1016/j.jaci.2016.02.046 |
| Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol. 2016 Nov 17;23(11):1407-1416. doi: 10.1016/j.chembiol.2016.09.016 | https://www.ncbi.nlm.nih.gov/pubmed/27818299 |
| Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS One. 2016 Apr 21;11(4):e0153847. doi: 10.1371/journal.pone.0153847 | https://www.ncbi.nlm.nih.gov/pubmed/27100179 |
| Lai X, Wolkenhauer O, Vera J. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 2016 Jul 27;44(13):6019-35. doi: 10.1093/nar/gkw550 | https://www.ncbi.nlm.nih.gov/pubmed/27317695 |
| Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J Infect Dis. 2016 Aug 1;214(3):454-63. doi: 10.1093/infdis/jiw171 | https://www.ncbi.nlm.nih.gov/pubmed/?term=27130431 |
| Schirm S, Ahnert P, Wienhold S, Mueller-Redetzky H, Nouailles-Kursar G, Loeffler M, Witzenrath M, Scholz M. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS One. 2016 May 19;11(5):e0156047. doi: 10.1371/journal.pone.0156047 | https://www.ncbi.nlm.nih.gov/pubmed/27196107 |
| Arakelyan A, Nersisyan L, Petrek M, Löffler-Wirth H, Binder H. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet. 2016 May 6;7:79. doi: 10.3389/fgene.2016.00079 | https://www.ncbi.nlm.nih.gov/pubmed/?term=27200087 |
| Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J Infect Dis. 2016 Jul 15;214(2):288-99. doi: 10.1093/infdis/jiw109 | https://www.ncbi.nlm.nih.gov/pubmed/26984146 |
| Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016 Apr 22;12(4) | http://www.ncbi.nlm.nih.gov/pubmed/?term=27105429 |
| Santos G, Nikolov S, Lai X, Eberhardt M, Dreyer FS, Paul S, Schuler G, Vera J. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep. 2016 Apr 26;6:24967 | http://www.ncbi.nlm.nih.gov/pubmed/?term=27113331 |
| Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol Biol. 2016;1386:135-79. doi: 10.1007/978-1-4939-3283-2_9 | https://www.ncbi.nlm.nih.gov/pubmed/26677184 |
| Schmeck B, Bertrams W, Lai X, Vera J. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol Biol. 2016;1386:119-33. doi: 10.1007/978-1-4939-3283-2_8 | https://www.ncbi.nlm.nih.gov/pubmed/26677183 |
| 2015 |
| Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect Immun. 2015;83(12):4617-29 | http://www.ncbi.nlm.nih.gov/pubmed/?term=26371127 |
| Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev. 2015;24(137):516-24 | http://www.ncbi.nlm.nih.gov/pubmed/?term=26324814 |
| 2014 |
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