CAPSyS

Systems Medicine of Community Acquired Pneumonia

 
 
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PUBLIKATIONEN

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2018
Berger S, Goekeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M, Nouailles G. Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia. Crit Care. 2018 Nov 1;22(1):287. doi: 10.1186/s13054-018-2224-5.https://www.ncbi.nlm.nih.gov/pubmed/?term=30382866
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J1 Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky H. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice. Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8.https://www.ncbi.nlm.nih.gov/pubmed/?term=30373626
Vera J, Santos G. Can Gamification Contribute to Computer Modeling-Driven Biomedical Research? Front Physiol. 2018 Jul 19;9:908. doi: 10.3389/fphys.2018.00908. eCollection 2018.https://www.ncbi.nlm.nih.gov/pubmed/?term=30072911
Santos G, Lai X, Eberhardt M, Vera J. Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling. Front Cell Infect Microbiol. 2018 May 15;8:159. doi: 10.3389/fcimb.2018.00159. eCollection 2018.https://www.ncbi.nlm.nih.gov/pubmed/29868515
Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD. Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia. Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA.https://www.ncbi.nlm.nih.gov/pubmed/29361238
2017
Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep. 2017 Sep 20;7(1):11988. doi: 10.1038/s41598-017-12154-4.https://www.ncbi.nlm.nih.gov/pubmed/?term=28931863
Schumann, B., Hahm, H.S., Parameswarappa, S.G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C.L., Seeberger, P.H., 2017. A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Sci Transl Med 9.http://doi.org/10.1126/scitranslmed.aaf5347
Jung, A.L., Hoffmann, K., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2017. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp.http://doi.org/10.1126/scitranslmed.aaf5347
Cantone M, Santos G, Wentker P, Lai X, Vera J. Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection. Front Physiol. 2017 Aug 30;8:645. doi: 10.3389/fphys.2017.00645https://www.ncbi.nlm.nih.gov/pubmed/?term=28912729
Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017 Jan 30. pii: 1502513. doi:10.4049/jimmunol.1502513https://www.ncbi.nlm.nih.gov/pubmed/?term=28137890
Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection andtargets NTAN1. PLoS One. 2017 Apr 26;12(4):e0176204. doi:10.1371/journal.pone.0176204https://www.ncbi.nlm.nih.gov/pubmed/28445535
2016
Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2016. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie 70, 372-378. http://doi.org/10.1055/s-0035-1563788
Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47-56.http://doi.org/10.1016/j.jaci.2016.02.046
Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol. 2016 Nov 17;23(11):1407-1416. doi: 10.1016/j.chembiol.2016.09.016https://www.ncbi.nlm.nih.gov/pubmed/27818299
Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS One. 2016 Apr 21;11(4):e0153847. doi: 10.1371/journal.pone.0153847https://www.ncbi.nlm.nih.gov/pubmed/27100179
Lai X, Wolkenhauer O, Vera J. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 2016 Jul 27;44(13):6019-35. doi: 10.1093/nar/gkw550https://www.ncbi.nlm.nih.gov/pubmed/27317695
Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J Infect Dis. 2016 Aug 1;214(3):454-63. doi: 10.1093/infdis/jiw171https://www.ncbi.nlm.nih.gov/pubmed/?term=27130431
Schirm S, Ahnert P, Wienhold S, Mueller-Redetzky H, Nouailles-Kursar G, Loeffler M, Witzenrath M, Scholz M. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS One. 2016 May 19;11(5):e0156047. doi: 10.1371/journal.pone.0156047https://www.ncbi.nlm.nih.gov/pubmed/27196107
Arakelyan A, Nersisyan L, Petrek M, Löffler-Wirth H, Binder H. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet. 2016 May 6;7:79. doi: 10.3389/fgene.2016.00079https://www.ncbi.nlm.nih.gov/pubmed/?term=27200087
Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J Infect Dis. 2016 Jul 15;214(2):288-99. doi: 10.1093/infdis/jiw109https://www.ncbi.nlm.nih.gov/pubmed/26984146
Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016 Apr 22;12(4)http://www.ncbi.nlm.nih.gov/pubmed/?term=27105429
Santos G, Nikolov S, Lai X, Eberhardt M, Dreyer FS, Paul S, Schuler G, Vera J. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep. 2016 Apr 26;6:24967http://www.ncbi.nlm.nih.gov/pubmed/?term=27113331
Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol Biol. 2016;1386:135-79. doi: 10.1007/978-1-4939-3283-2_9https://www.ncbi.nlm.nih.gov/pubmed/26677184
Schmeck B, Bertrams W, Lai X, Vera J. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol Biol. 2016;1386:119-33. doi: 10.1007/978-1-4939-3283-2_8https://www.ncbi.nlm.nih.gov/pubmed/26677183
2015
Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect Immun. 2015;83(12):4617-29http://www.ncbi.nlm.nih.gov/pubmed/?term=26371127
Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev. 2015;24(137):516-24http://www.ncbi.nlm.nih.gov/pubmed/?term=26324814
Du Bois I, Marsico A, Bertrams W, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck B. Activation of probacterial host factor TNFAIP2 in Legionella pneumophila infection. re-submitted to Eur Respir J. 11/2015http://www.ncbi.nlm.nih.gov/pubmed/27130431
Lienau J, Müller-Redetzky H, Suttorp N, Witzenrath M. Neue pathogenetische Konzepte und pharmakologische Studien zur adjuvanten Therapie bei schwerer Pneumonie. Pneumologie 2015; 69: 1–7http://www.ncbi.nlm.nih.gov/pubmed/?term=26637049
2014
Witzenrath M. Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff! Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5http://www.ncbi.nlm.nih.gov/pubmed/?term=24930525