CAPSyS

Systems Medicine of Community Acquired Pneumonia

 
 
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2023
Pennitz P, Goekeri C, Trimpert J, Wyler E, Ebenig A, Weissfuss C, Mühlebach MD, Witzenrath M, Nouailles G. Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis. STAR Protoc. 2022 Dec 20;4(1):101957. https://pubmed.ncbi.nlm.nih.gov/36542521/
2022
Felten M, Ferencik S, Teixeira Alves LG, Letsiou E, Lienau J, Müller-Redetzky HC, Langenhagen AK, Voß A, Dietert K, Kershaw O, Gruber AD, Michalick L, Kuebler WM, Ananthasubramaniam B, Maier B, Uhlenhaut H, Kramer A, Witzenrath M. Ventilator-induced Lung Injury Is Modulated by the Circadian Clock. Am J Respir Crit Care Med. 2022 Dec 8. https://pubmed.ncbi.nlm.nih.gov/36480958/
Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F. Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study. Infection. 2022 Dec;50(6):1441-1452. https://pubmed.ncbi.nlm.nih.gov/35420370/
Vlaar APJ, Witzenrath M, van Paassen P, Heunks LMA, Mourvillier B, de Bruin S, Lim EHT, Brouwer MC, Tuinman PR, Saraiva JFK, Marx G, Lobo SM, Boldo R, Simon-Campos JA, Cornet AD, Grebenyuk A, Engelbrecht JM, Mukansi M, Jorens PG, Zerbib R, Rückinger S, Pilz K, Guo R, van de Beek D, Riedemann NC; PANAMO study group. Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Respir Med. 2022 Dec;10(12):1137-1146. https://pubmed.ncbi.nlm.nih.gov/36087611/
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC. Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus. Sci Rep. 2022 Nov 29;12(1):20608. https://pubmed.ncbi.nlm.nih.gov/36446841/
Lingscheid T, Kinzig M, Krüger A, Müller N, Bölke G, Tober-Lau P, Münn F, Kriedemann H, Witzenrath M, Sander LE, Sörgel F, Kurth F. Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis. Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0122922. https://pubmed.ncbi.nlm.nih.gov/36286542/
Ni B, Chen S, Ryan KA, Maitland ML, Farrar JS, Witzenrath M, Gubier B, Serdjebi C, Bertotti K, Wang R, Salloum FN, Marino L, Mitchell BD, Celi FS. Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome. Mol Metab. 2022 Nov;65:101588. https://pubmed.ncbi.nlm.nih.gov/36055577/
Steinbeis F, Knape P, Mittermaier M, Helbig ET, Tober-Lau P, Thibeault C, Lippert LJ, Xiang W, Müller-Plathe M, Steinbrecher S, Meyer HJ, Ring RM, Ruwwe-Glösenkamp C, Alius F, Li Y, Müller-Redetzky H, Uhrig A, Lingscheid T, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Witzenrath M, Zoller T. Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents. Respir Med. 2022 Oct;202:106968. https://pubmed.ncbi.nlm.nih.gov/36081267/
Lask A, Gutbier B, Kershaw O, Nouailles G, Gruber AD, Müller-Redetzky HC, Chackowicz S, Hamilton DA, Van Slyke P, Witzenrath M. Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice. Sci Rep. 2022 Sep 15;12(1):15531. https://pubmed.ncbi.nlm.nih.gov/36109537/
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G. A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics. Eur Respir Rev. 2022 Jul 27;31(165):220056. https://pubmed.ncbi.nlm.nih.gov/35896273/
Kheifetz Y, Kirsten H, Scholz M. On the Parametrization of Epidemiologic Models-Lessons from Modelling COVID-19 Epidemic. Viruses. 2022 Jul 2;14(7):1468. https://pubmed.ncbi.nlm.nih.gov/35891447/
Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G. Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection. J Clin Invest. 2022 Jul 1;132(13):e150951. https://pubmed.ncbi.nlm.nih.gov/35503420/
Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group; Rubelt F, Heidecker B. Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19. EClinicalMedicine. 2022 Jun;48:101438. https://pubmed.ncbi.nlm.nih.gov/35600330/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J. Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics. Mol Ther. 2022 May 4;30(5):1952-1965. https://pubmed.ncbi.nlm.nih.gov/35339689/
Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group; Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 Feb 8;7(3):e149870. https://pubmed.ncbi.nlm.nih.gov/35132956/
Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group. A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany. Eur Respir J. 2022 Feb 3;59(2):2102432. https://pubmed.ncbi.nlm.nih.gov/34824055/
Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M. Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia. Genes (Basel). 2022 Jan 6;13(1):111. https://pubmed.ncbi.nlm.nih.gov/35052452/
2021
Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M. Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection. Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI); Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell. 2021 Dec 22;184(26):6243-6261.e27. https://pubmed.ncbi.nlm.nih.gov/34914922/
Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M. Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst. Sci Rep. 2021 May 5;11(1):9529. https://pubmed.ncbi.nlm.nih.gov/33953279/
Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS. Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings. Eur J Heart Fail. 2021 Nov;23(11):1891-1902. https://pubmed.ncbi.nlm.nih.gov/33932255/
Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine. 2021 Oct;40:101099. https://pubmed.ncbi.nlm.nih.gov/34490415/
Jung AL, Schmeck B, Wiegand M, Bedenbender K, Benedikter BJ. The clinical role of host and bacterial-derived extracellular vesicles in pneumonia. Adv Drug Deliv Rev. 2021 Sep;176:113811. https://pubmed.ncbi.nlm.nih.gov/34022269/
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Ralser M, Kurth F. A time-resolved proteomic and prognostic map of COVID-19. Cell Syst. 2021 Aug 18;12(8):780-794.e7. https://pubmed.ncbi.nlm.nih.gov/34139154/
Witzenrath M, Kuebler WM. The CypA-netics of Ventilator-induced Lung Injury. Am J Respir Crit Care Med. 2021 Aug 15;204(4):385-387. https://pubmed.ncbi.nlm.nih.gov/34033522/
Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M. Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19. Nat Commun. 2021 Aug 11;12(1):4869. https://pubmed.ncbi.nlm.nih.gov/34381043/
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH. CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity. Infection. 2021 Aug;49(4):757-762. https://pubmed.ncbi.nlm.nih.gov/33825125/
Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M. Ultra-fast proteomics with Scanning SWATH. Nat Biotechnol. 2021 Jul;39(7):846-854. https://pubmed.ncbi.nlm.nih.gov/33767396
Jagdmann S, Berchtold D, Gutbier B, Witzenrath M, Meisel A, Meisel C, Dames C. Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections. J Neuroimmunol. 2021 Jun 15;355:577568. https://pubmed.ncbi.nlm.nih.gov/33862420/
Roessler FK, Benedikter BJ, Schmeck B, Bar N. Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples. Sci Rep. 2021 May 13;11(1):10258. https://pubmed.ncbi.nlm.nih.gov/33986404/
Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M. Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure. Cells. 2021 Dec 18;10(12):3581. https://pubmed.ncbi.nlm.nih.gov/34944089/
Ochs M, Timm S, Elezkurtaj S, Horst D, Meinhardt J, Heppner FL, Weber-Carstens S, Hocke AC, Witzenrath M. Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient. Eur Respir J. 2021 May 6;57(5):2004165. https://pubmed.ncbi.nlm.nih.gov/33446606
Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN. Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes. RNA Biol. 2021 May;18(5):604-618. https://pubmed.ncbi.nlm.nih.gov/33622174
Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M. Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L916-L925. https://pubmed.ncbi.nlm.nih.gov/33655757
Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B. Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection. Life Sci. 2021 Apr 1;270:119158. https://pubmed.ncbi.nlm.nih.gov/33545200
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM. Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure. Eur Respir J. 2021 Mar 11;57(3):2002384. https://pubmed.ncbi.nlm.nih.gov/33154030/
Vera J, Lischer C, Nenov M, Nikolov S, Lai X, Eberhardt M. Mathematical Modelling in Biomedicine: A Primer for the Curious and the Skeptic. Int J Mol Sci. 2021 Jan 7;22(2):547. https://pubmed.ncbi.nlm.nih.gov/33430432
Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A. Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells. J Cyst Fibros. 2021 Jan;20(1):140-148. (juni 2020 epub) https://pubmed.ncbi.nlm.nih.gov/32534959
2020
Karwelat D, Schmeck B, Ringel M, Benedikter BJ, Hübner K, Beinborn I, Maisner A, Schulte LN, Vollmeister E. Influenza virus-mediated suppression of bronchial Chitinase-3-like 1 secretion promotes secondary pneumococcal infection. FASEB J. 2020 Dec;34(12):16432-16448. https://pubmed.ncbi.nlm.nih.gov/33095949
Ahnert P, Scholz M. modellierung von infektionserkrankungen der atemwege. Systemmedizinische Modellierung von Therapieoptionen bei ambulant erworbener Pneumonie und COVID-19. In Systembiologie.de. Ausgabe 13 Dezember 2020. https://www.systembiologie.de/lw_resource/datapool/systemfiles/elements/files/B6AA5AC509E249CBE0537E695E866DB2/live/document/PTJ-007_gesundhyte_13_2020_201217_WEB_300dpi_klein.pdf
Schirm S, Ahnert P, Berger S, Nouailles G, Wienhold SM, Müller-Redetzky H, Suttorp N, Loeffler M, Witzenrath M, Scholz M. A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection. PLoS One. 2020 Dec 3;15(12):e0243147. https://pubmed.ncbi.nlm.nih.gov/33270742
Mittermaier M, Pickerodt P, Kurth F, de Jarcy LB, Uhrig A, Garcia C, Machleidt F, Pergantis P, Weber S, Li Y, Breitbart A, Bremer F, Knape P, Dewey M, Doellinger F, Weber-Carstens S, Slutsky AS, Kuebler WM, Suttorp N, Müller-Redetzky H. Evaluation of PEEP and prone positioning in early COVID-19 ARDS. EClinicalMedicine. 2020 Nov;28:100579. https://pubmed.ncbi.nlm.nih.gov/33073217
Santos G, Vera J. The Role of Age, Neutrophil Infiltration and Antibiotics Timing in the Severity of Streptococcus pneumoniae Pneumonia. Insights from a Multi-Level Mathematical Model Approach. Int J Mol Sci. 2020 Nov 10;21(22):8428. doi: 10.3390/ijms21228428. https://pubmed.ncbi.nlm.nih.gov/33182614/
Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A. SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature. 2020 Nov;587(7833):270-274. https://pubmed.ncbi.nlm.nih.gov/32726801
Schmidt M, Hopp L, Arakelyan A, Kirsten H, Engel C, Wirkner K, Krohn K, Burkhardt R, Thiery J, Loeffler M, Loeffler-Wirth H, Binder H. The Human Blood Transcriptome in a Large Population Cohort and Its Relation to Aging and Health. Front Big Data. 2020 Oct 30;3:548873. https://pubmed.ncbi.nlm.nih.gov/33693414
Korfhage N, Mühling M, Ringshandl S, Becker A, Schmeck B, Freisleben B. Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion. PLoS Comput Biol. 2020 Sep 8;16(9):e1008179. https://pubmed.ncbi.nlm.nih.gov/32898132
Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat Biotechnol. 2020 Aug;38(8):970-979. https://pubmed.ncbi.nlm.nih.gov/32591762
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M. Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection. Cell Syst. 2020 Jul 22;11(1):11-24.e4. https://pubmed.ncbi.nlm.nih.gov/32619549
Nikoghosyan M, Schmidt M, Margaryan K, Loeffler-Wirth H, Arakelyan A, Binder H. SOMmelier-Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. Genes (Basel). 2020 Jul 17;11(7):817. https://pubmed.ncbi.nlm.nih.gov/32709105
Mikolajewska, A., and M. Witzenrath (2020). „Ambulant erworbene Pneumonie bei Erwachsenen.“ Dtsch med Wochenschr 145(06): 359–370. http://doi.org/10.1055/a-0993-0874
Sanapala SR, Seco BMS, Baek JY, Awan SI, Pereira CL, Seeberger PH. Chimeric oligosaccharide conjugate induces opsonic antibodies against Streptococcus pneumoniae serotypes 19A and 19F. Chem Sci. 2020 Jun 26;11(28):7401-7407. https://pubmed.ncbi.nlm.nih.gov/34123020
Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN. Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):9042-9053. doi: 10.1073/pnas.1920393117. Epub 2020 Apr 2. https://www.ncbi.nlm.nih.gov/pubmed/32209695
Ochs M, Hegermann J, Lopez-Rodriguez E, Timm S, Nouailles G, Matuszak J, Simmons S, Witzenrath M, Kuebler WM. On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx. Int J Mol Sci. 2020 Apr 27;21(9):3075. https://pubmed.ncbi.nlm.nih.gov/32349261
Müller-Redetzky H, Kellermann U, Wienhold SM, Gutbier B, Lienau J, Hellwig K, Reppe K, Letsiou E, Tschernig T, Scholz M, Ahnert P, Maasch C, Hoehlig K, Klussmann S, Vater A, Firsching TC, Hoppe J, Suttorp N, Witzenrath M. Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis. Anesthesiology. 2020 Feb 20. doi: 10.1097/ALN.0000000000003149. https://www.ncbi.nlm.nih.gov/pubmed/32101978
Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B. A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1. mBio. 2020 Mar 24;11(2). pii: e03155-19. doi: 10.1128/mBio.03155-19. https://www.ncbi.nlm.nih.gov/pubmed/32209695
Thalheim T, Hopp L, Herberg M, Siebert S, Kerner C, Quaas M, Schweiger MR, Aust G, Galle J. Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells. Int J Mol Sci. 2020 Mar 12;21(6):1941. https://pubmed.ncbi.nlm.nih.gov/32178409
Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E. NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells. Cell Signal. 2020 Mar;67:109498. doi:10.1016/j.cellsig.2019.109498. Epub 2019 Dec 16. https://www.ncbi.nlm.nih.gov/pubmed/31837465
Przybilla J, Ahnert P, Bogatsch H, Bloos F, Brunkhorst FM, SepNet Critical Care Trials Group, Progress Study Group, Bauer M, Loeffler M, Witzenrath M, Suttorp N, Scholz M. Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia. J Clin Med. 2020 Feb 5;9(2). pii: E393. doi: 10.3390/jcm9020393. https://www.ncbi.nlm.nih.gov/pubmed/32121038
Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier CF, Vera J, Schmeck B. Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation. Sci Rep. 2020 Jan 14;10(1):241. doi: 10.1038/s41598-019-57108-0. https://www.ncbi.nlm.nih.gov/pubmed/31937830
Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, Auf Dem Brinke K, Timmesfeld N, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Suttorp N, Schmeck B. Surface Proteome of Plasma Extracellular Vesicles as Biomarkers for Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease. J Infect Dis. 2020 Jan 2;221(2):325-335. doi: 10.1093/infdis/jiz460. https://www.ncbi.nlm.nih.gov/pubmed/31617573
2019
Jensen AV, Baunbæk Egelund G, Bang Andersen S, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P, Faurholt-Jepsen D; Members of the CAPNETZ study group except the authors:. The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study. Ann Am Thorac Soc. 2019 Dec;16(12):1518-1526. https://pubmed.ncbi.nlm.nih.gov/31437014
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. https://www.ncbi.nlm.nih.gov/pubmed/31844089
Lindhauer NS, Bertrams W, Pöppel A, Herkt CE, Wesener A, Hoffmann K, Greene B,Van Der Linden M, Vilcinskas A, Seidel K, Schmeck B. Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcuspneumoniae. Virulence. 2019 Dec;10(1):902-909.https://www.ncbi.nlm.nih.gov/pubmed/31657264
Meyer TC, Schmidt F, Steinke J, Bröker BM, Völker U, Michalik S. Technical report: xMAPr - High-dynamic-range (HDR) quantification of antigen-specific antibody binding. J Proteomics. 2019 Nov 1:103577. doi: 10.1016/j.https://www.ncbi.nlm.nih.gov/pubmed/31683064
Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber AD,Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, HainT, Zahlten J. Peptidoglycan Recognition Protein 4 Limits Bacterial Clearance and Inflammation in Lungs by Control of the Gut Microbiota. Front Immunol. 2019 Sep20;10:2106. doi: 10.3389/fimmu.2019.02106. eCollection 2019.https://www.ncbi.nlm.nih.gov/pubmed/31616404
Blankenburg S, Hentschker C, Nagel A, Hildebrandt P, Michalik S, Dittmar D, Surmann K, Völker U. Improving Proteome Coverage for Small Sample Amounts: An Advanced Method for Proteomics Approaches with Low Bacterial Cell Numbers. Proteomics. 2019 Sep 18:e1900192. doi: 10.1002/pmic.201900192.https://www.ncbi.nlm.nih.gov/pubmed/31532911
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019 Aug 7. pii: JVI.00649-19. doi: 10.1128/JVI.00649-19.https://www.ncbi.nlm.nih.gov/pubmed/31391268
Franssen FM, Alter P, Bar N, Benedikter BJ, Iurato S, Maier D, Maxheim M, Roessler FK, Spruit MA, Vogelmeier CF, Wouters EF, Schmeck B. Personalized medicine for patients with COPD: where are we? Int J Chron Obstruct Pulmon Dis. 2019 Jul 9;14:1465-1484. https://pubmed.ncbi.nlm.nih.gov/31371934
Brack MC, Lienau J, Kuebler WM, Witzenrath M. Cardiovascular sequelae of pneumonia. Curr Opin Pulm Med. 2019 May;25(3):257-262. doi: 10.1097/MCP.0000000000000584.https://www.ncbi.nlm.nih.gov/pubmed/30893107
Nikoghosyan M, Hakobyan S, Hovhannisyan A, Loeffler-Wirth H, Binder H, Arakelyan A. Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians - A Machine Learning Approach. Front Genet. 2019 Apr 26;10:394. https://pubmed.ncbi.nlm.nih.gov/31105750
Loeffler-Wirth H, Kreuz M, Hopp L, Arakelyan A, Haake A, Cogliatti SB, Feller AC, Hansmann ML, Lenze D, Möller P, Müller-Hermelink HK, Fortenbacher E, Willscher E, Ott G, Rosenwald A, Pott C, Schwaenen C, Trautmann H, Wessendorf S, Stein H, Szczepanowski M, Trümper L, Hummel M, Klapper W, Siebert R, Loeffler M, Binder H; German Cancer Aid consortium Molecular Mechanisms for Malignant Lymphoma. A modular transcriptome map of mature B cell lymphomas. Genome Med. 2019 Apr 30;11(1):27. https://pubmed.ncbi.nlm.nih.gov/31039827
Wienhold SM, Lienau J, Witzenrath M. Towards Inhaled Phage Therapy in Western Europe. Viruses. 2019 Mar 23;11(3). pii: E295. doi: 10.3390/v11030295.https://www.ncbi.nlm.nih.gov/pubmed/30909579
Regier Y, Komma K, Weigel M, Kraiczy P, Laisi A, Pulliainen AT, Hain T, Kempf VAJ. Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany. Parasit Vectors. 2019 Jan 7;12(1):11. https://pubmed.ncbi.nlm.nih.gov/30616666
Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B. Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. J Infect Dis. 2019 Jan 29;219(4):540-543. https://pubmed.ncbi.nlm.nih.gov/30239899
Schulte LN, Bertrams W, Stielow C, Schmeck B. ncRNAs in Inflammatory and Infectious Diseases. Methods Mol Biol. 2019;1912:3-32. https://pubmed.ncbi.nlm.nih.gov/30635888
2018
Regier Y, Komma K, Weigel M, Pulliainen AT, Göttig S, Hain T, Kempf VAJ. Microbiome Analysis Reveals the Presence of Bartonella spp. and Acinetobacter spp. in Deer Keds (Lipoptena cervi). Front Microbiol. 2018 Dec 20;9:3100. https://pubmed.ncbi.nlm.nih.gov/30619179
Kaplonek P, Khan N, Reppe K, Schumann B, Emmadi M, Lisboa MP, Xu FF, Calow ADJ, Parameswarappa SG, Witzenrath M, Pereira CL, Seeberger PH. Improving vaccines against Streptococcus pneumoniae using synthetic glycans. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13353-13358. doi: 10.1073/pnas.1811862115.https://www.ncbi.nlm.nih.gov/pubmed/30530654
Berger S, Goekeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M, Nouailles G. Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia. Crit Care. 2018 Nov 1;22(1):287. doi: 10.1186/s13054-018-2224-5.https://www.ncbi.nlm.nih.gov/pubmed/?term=30382866
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky H. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice. Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8.https://www.ncbi.nlm.nih.gov/pubmed/?term=30373626
Marin-Sanguino A, Vera J, Alves R. Editorial: Foundations of Theoretical Approaches in Systems Biology. Front Genet. 2018 Aug 15;9:290. doi: 10.3389/fgene.2018.00290.https://www.ncbi.nlm.nih.gov/pubmed/30158950
Vera J, Santos G. Can Gamification Contribute to Computer Modeling-Driven Biomedical Research? Front Physiol. 2018 Jul 19;9:908. doi: 10.3389/fphys.2018.00908. eCollection 2018.https://www.ncbi.nlm.nih.gov/pubmed/?term=30072911
Hopp L, Loeffler-Wirth H, Nersisyan L, Arakelyan A, Binder H. Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome. Front Immunol. 2018 Jul 17;9:1620. doi: 10.3389/fimmu.2018.01620https://www.ncbi.nlm.nih.gov/pubmed/30065722
Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS Study Groups ‡. Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia. Am J Respir Crit Care Med. 2018 Jul 15;198(2):220-231. doi: 10.1164/rccm.201708-1733OC.https://www.ncbi.nlm.nih.gov/pubmed/29447449
Santos G, Lai X, Eberhardt M, Vera J. Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling. Front Cell Infect Microbiol. 2018 May 15;8:159. doi: 10.3389/fcimb.2018.00159. eCollection 2018.https://www.ncbi.nlm.nih.gov/pubmed/29868515
Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD. Digital Image Analyses on Whole-Lung Slides in Mouse Models of Acute Pneumonia. Am J Respir Cell Mol Biol. 2018 Apr;58(4):440-448. doi: 10.1165/rcmb.2017-0337MA.https://www.ncbi.nlm.nih.gov/pubmed/29361238
Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH. Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1. ACS Cent Sci. 2018 Mar 28;4(3):357-361. doi: 10.1021/acscentsci.7b00504.https://www.ncbi.nlm.nih.gov/pubmed/29632881
Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.https://www.ncbi.nlm.nih.gov/pubmed/29298188
Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznicka M, Cambier J, Witzenrath M, Schumann RR, Suttorp N, Opitz B. The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infect Immun. 2018 Feb 20;86(3). pii: e00849-17. doi: 10.1128/IAI.00849-17.https://www.ncbi.nlm.nih.gov/pubmed/29263110
Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B; CAPNETZ Study Group. The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. PLoS Pathog. 2018 Jan 3;14(1):e1006829. doi: 10.1371/journal.ppat.1006829.https://www.ncbi.nlm.nih.gov/pubmed/29298342
2017
Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ); German Community-Acquired Pneumonia Competence Network (CAPNETZ). Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study. Clin Infect Dis. 2017 Nov 29;65(12):2091-2098. doi: 10.1093/cid/cix703.https://www.ncbi.nlm.nih.gov/pubmed/29095981
Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Hoang VC, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M. Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia. Crit Care. 2017 Nov 13;21(1):274. doi: 10.1186/s13054-017-1851-6.https://www.ncbi.nlm.nih.gov/pubmed/29132435
Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M. A Semi-Synthetic Glycoconjugate Vaccine Candidate for Carbapenem-Resistant Klebsiella pneumoniae. Angew Chem Int Ed Engl. 2017 Nov 6;56(45):13973-13978. doi: 10.1002/anie.201700964.https://www.ncbi.nlm.nih.gov/pubmed/28815890
Arakelyan A, Nersisyan L, Poghosyan D, Khondkaryan L, Hakobyan A, Löffler-Wirth H, Melanitou E, Binder H. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS One. 2017 Nov 3;12(11):e0187572. doi: 10.1371/journal.pone.0187572.https://www.ncbi.nlm.nih.gov/pubmed/?term=29099860
Emmadi M, Khan N, Lykke L, Reppe K, G Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH. A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease. J Am Chem Soc. 2017 Oct 18;139(41):14783-14791. doi: 10.1021/jacs.7b07836.https://www.ncbi.nlm.nih.gov/pubmed/28945368
Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH. Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11063-11068. doi: 10.1073/pnas.1706875114.https://www.ncbi.nlm.nih.gov/pubmed/28973947
Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study. Sci Rep. 2017 Sep 20;7(1):11988. doi: 10.1038/s41598-017-12154-4.https://www.ncbi.nlm.nih.gov/pubmed/?term=28931863
Cantone M, Santos G, Wentker P, Lai X, Vera J. Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection. Front Physiol. 2017 Aug 30;8:645. doi: 10.3389/fphys.2017.00645https://www.ncbi.nlm.nih.gov/pubmed/?term=28912729
Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep. 2017 Jul 24;7(1):6301. doi: 10.1038/s41598-017-06443-1.https://www.ncbi.nlm.nih.gov/pubmed/28740179
Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection andtargets NTAN1. PLoS One. 2017 Apr 26;12(4):e0176204. doi:10.1371/journal.pone.0176204https://www.ncbi.nlm.nih.gov/pubmed/28445535
Schumann, B., Hahm, H.S., Parameswarappa, S.G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L.-A., Witzenrath, M., Anish, C., Pereira, C.L., Seeberger, P.H., 2017. A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine. Sci Transl Med. 2017 Mar 8;9(380). pii: eaaf5347. doi: 10.1126/scitranslmed.aaf5347.https://www.ncbi.nlm.nih.gov/pubmed/28275152
Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017 Mar 1;198(5):2191-2201. doi: 10.4049/jimmunol.1502513.https://www.ncbi.nlm.nih.gov/pubmed/?term=28137890
Jung, A.L., Hoffmann, K., Herkt, C.E., Schulz, C., Bertrams, W., Schmeck, B., 2017. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp. 2017 Feb 22;(120). doi: 10.3791/55146.https://www.ncbi.nlm.nih.gov/pubmed/28287548
2016
Lienau, J., Müller-Redetzky, H., Suttorp, N., Witzenrath, M., 2016. [New Pathogenetic Concepts and Pharmacological Studies on Adjuvant Therapy in Severe Pneumonia]. Pneumologie 70, 372-378. http://doi.org/10.1055/s-0035-1563788
Garn, H., Bahn, S., Baune, B.T., Binder, E.B., Bisgaard, H., Chatila, T.A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., Gern, J., Haahtela, T., Kircher, T., Müller-Ladner, U., Neurath, M.F., Preissner, K.T., Reinhardt, C., Rook, G., Russell, S., Schmeck, B., Stappenbeck, T., Steinhoff, U., van Os, J., Weiss, S., Zemlin, M., Renz, H., 2016. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J. Allergy Clin. Immunol. 138, 47-56.http://doi.org/10.1016/j.jaci.2016.02.046
Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection. Cell Chem Biol. 2016 Nov 17;23(11):1407-1416. doi: 10.1016/j.chembiol.2016.09.016https://www.ncbi.nlm.nih.gov/pubmed/27818299
Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS One. 2016 Apr 21;11(4):e0153847. doi: 10.1371/journal.pone.0153847https://www.ncbi.nlm.nih.gov/pubmed/27100179
Lai X, Wolkenhauer O, Vera J. Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res. 2016 Jul 27;44(13):6019-35. doi: 10.1093/nar/gkw550https://www.ncbi.nlm.nih.gov/pubmed/27317695
Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT. Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2. J Infect Dis. 2016 Aug 1;214(3):454-63. doi: 10.1093/infdis/jiw171https://www.ncbi.nlm.nih.gov/pubmed/?term=27130431
Schirm S, Ahnert P, Wienhold S, Mueller-Redetzky H, Nouailles-Kursar G, Loeffler M, Witzenrath M, Scholz M. A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice. PLoS One. 2016 May 19;11(5):e0156047. doi: 10.1371/journal.pone.0156047https://www.ncbi.nlm.nih.gov/pubmed/27196107
Arakelyan A, Nersisyan L, Petrek M, Löffler-Wirth H, Binder H. Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet. 2016 May 6;7:79. doi: 10.3389/fgene.2016.00079https://www.ncbi.nlm.nih.gov/pubmed/?term=27200087
Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J Infect Dis. 2016 Jul 15;214(2):288-99. doi: 10.1093/infdis/jiw109https://www.ncbi.nlm.nih.gov/pubmed/26984146
Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016 Apr 22;12(4)http://www.ncbi.nlm.nih.gov/pubmed/?term=27105429
Santos G, Nikolov S, Lai X, Eberhardt M, Dreyer FS, Paul S, Schuler G, Vera J. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis. Sci Rep. 2016 Apr 26;6:24967http://www.ncbi.nlm.nih.gov/pubmed/?term=27113331
Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol Biol. 2016;1386:135-79. doi: 10.1007/978-1-4939-3283-2_9https://www.ncbi.nlm.nih.gov/pubmed/26677184
Schmeck B, Bertrams W, Lai X, Vera J. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol Biol. 2016;1386:119-33. doi: 10.1007/978-1-4939-3283-2_8https://www.ncbi.nlm.nih.gov/pubmed/26677183
2015
Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M. Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. Infect Immun. 2015;83(12):4617-29http://www.ncbi.nlm.nih.gov/pubmed/?term=26371127
Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M. Therapeutic strategies in pneumonia: going beyond antibiotics. Eur Respir Rev. 2015;24(137):516-24http://www.ncbi.nlm.nih.gov/pubmed/?term=26324814
2014
Witzenrath M. Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff! Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5http://www.ncbi.nlm.nih.gov/pubmed/?term=24930525