The interplay between mathematical modeling, verification of results in laboratory experiments, and detailed patient characterization leads to a better understanding of barrier failure in pneumonia. This in turn is incorporated into new mathematical models. This feedback-loop is at the heart of the systems medicine approach which will be followed in five sub projects:

Titel

Leitung

Integrative Genetic Analysis and Biomathematical Modelling of Systemic Inflammation

Leipzig

Deep phenotyping in patients with severe CAP and new analyses in established cohorts

Berlin

Mathematical modelling of pneumonia pathophysiology

Erlangen

Experimental modelling and validation of pneumonia pathophysiology

Marburg, Berlin

Platform for Data-Integration, Communication, Data Mining, and Project Management

Leipzig